–Commentary by Susan Morey, PharmD. Pharmacy Practice Resident
A true allergy to penicillin is known to occur in less than 10% of patients exposed to penicillin. 1, 2 The cross-reactivity to cephalosporins has been reported to be …
Category: Pharmacology
Clinical Correlations
Clinical Commentary: The Travesty of Grinding Axes with Science: Rosiglitazone and Cardiac Risk
June 12, 2007
Welcome to our first blog commentary. One of the purposes of the blog is to generate discussion about issues in health care. This “Clinical Commentary” section is an invitation to our housestaff and faculty to submit their own thoughts and viewpoints …
Not So Rosi…
May 24, 2007
Commentary by Seagram Villagomez MD, Chief Resident
Since its approval in 1999, nearly 1 million Americans have used the thiazolidinedione (TZD) rosiglitazone (Avandia – GlaxoSmithKline) for the treatment of Type 2 Diabetes. Â However, in a drug class which …
Clinical Pharmacy Corner-The Thiazides
May 17, 2007Â We’d like to introduce you to Clinical Correlations’ newest feature-Clinical Pharmacy Corner. This will be a bimonthly pharmacy themed post which will tackle both basic and complicated pharmacy issues. We will review the mechanisms of actions of various classes of medications, a worthwhile refresher for those of us …
ShortCuts-The War on the Pharmaceutical Industry Edition
May 14, 2007
Welcome to our first theme issue of ShortCuts. This week, we decided to focus on the tribulations of the pharmaceutical industry, which recently seems to be plagued by new FDA advisories and NY Times exposés.
The first bad news for pharmaceutical companies …
Statin Pleiotropy: Unique Roles for a Common Medication
April 26, 2007
By: Melissa Freeman, MD, PGY1
For over a decade now, statins, or 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, have facilitated millions of patients in the management of their atherosclerosis. Statins are known for their ability to reduce hepatic lipoproteins, up-regulate …
First Direct Renin Inhibitor Approved for Hypertension
March 29, 2007
Commentary By: Josh Olstein, PGY-3
Earlier this month the FDA approved Tekturna (aliskiren) the first drug in a novel class of antihypertensives that work by directly inhibiting renin. While Novartis has yet to release pricing information, don’t expect to see this …
Does the Overuse of Macrolides Lead to Antibiotic Resistance?
March 12, 2007
Commentary By: Danise Schiliro, PGY-3
Although intuitively we always worry about creating drug resistance when using antibiotics, there is a surprising lack of well done studies that show a clear causal effect of antibiotic use on the development of subsequent drug resistance. …