By: Allen Fu
Ischemic stroke, defined by the extended loss of cerebral blood flow due to vessel occlusion, affected 77 million individuals, caused 63 million disability adjusted life-years, and caused 3.3 …
Category: Systems
Clinical Correlations
Peripheral Artery Disease: Underrecognized, Underdiagnosed and Undertreated
July 15, 2026
By: Richard Ni
Peer Reviewed
Peripheral artery disease (PAD) is a common manifestation of atherosclerotic cardiovascular disease that remains underrecognized compared to coronary artery disease (CAD) and cerebrovascular disease (CVD). While myocardial infarction and stroke are widely known …
Immunosenescence: Viral Reactivation in the Aging Immune System
June 22, 2026
By Madeline Kowalski
Peer Reviewed
A 91-year-old woman with no chronic illness,1 who until recently lived independently, developed rapidly progressive dementia and ataxia over several months. A paraneoplastic syndrome was suspected, yet an extensive workup revealed no malignancy. MRI revealed multifocal white-matter lesions, …
The History of Pacemakers and Where They Are Heading
June 2, 2026
By: David Willett
Peer reviewed
The story of the pacemaker begins in 1918 in New York City, where Dr. Albert Hyman spent years following his residency studying …
To Treat or Not to Treat: Rethinking the Positive Urine Culture
April 10, 2026By Bennett Yang
Peer Reviewed
An 84-year-old woman presents to the emergency department with fatigue and mild confusion. Her vitals are stable, she’s afebrile, and her exam is unremarkable. Labs are mostly normal, but the urinalysis shows moderate leukocyte esterase and bacteria. A urine culture is sent, and a broad-spectrum antibiotic is …
The Myth of 98.6° Fahrenheit: Rethinking the “Normal” Body Temperature
March 23, 2026
By Allen Khudaverdyan
Peer Reviewed
For over a century, 98.6° Fahrenheit (37° Celsius) has been etched into our collective consciousness as the “normal” human body temperature. From routine check-ups to COVID-19 …
Rethinking Alcohol Use Disorder Through GLP-1 Agonism
February 19, 2026
By Joshua Wang
Peer Reviewed
Dan never imagined his nightly struggle with alcohol cravings might be cured with his diabetes medication. Yet, a few months after starting semaglutide for his blood …
Stimulant Prescribing in Primary Care: Evidence and Best Practices
January 22, 2026
By Ashley Lewis
Peer Reviewed
In the US, patients experience serious barriers to accessing mental healthcare. Over half of counties in the US lack a psychiatrist, and most patients with mental illness did …