By: Timothy Liu
Peer Reviewed
Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer mortality in the United States, and while professional society guidelines for high-risk surveillance exist, they remain without the federal endorsement needed to make them …
By: Grace von Oiste
Peer Reviewed
The Case for Statins
High intensity statin therapy routinely produces low-density lipoprotein cholesterol (LDL-C) reductions of 50% or more, an effect that is both dramatic and highly predictable. Few drug classes in cardiovascular medicine offer …
By: Peter Lais
Peer Reviewed
A run-in period (“run-in”) is a pre-randomization phase in a randomized controlled trial (RCT) in which participants receive a placebo, investigational intervention, or other therapies to assess adherence, tolerability, and placebo responsiveness. Those who demonstrate nonadherence, intolerance of side …
By: Allen Fu
Ischemic stroke, defined by the extended loss of cerebral blood flow due to vessel occlusion, affected 77 million individuals, caused 63 million disability adjusted life-years, and caused …
By: Richard Ni
Peer Reviewed
Peripheral artery disease (PAD) is a common manifestation of atherosclerotic cardiovascular disease that remains underrecognized compared to coronary artery disease (CAD) and cerebrovascular disease (CVD). While myocardial infarction and stroke are widely …
By Madeline Kowalski
Peer Reviewed
A 91-year-old woman with no chronic illness,1 who until recently lived independently, developed rapidly progressive dementia and ataxia over several months. A paraneoplastic syndrome was suspected, yet an extensive workup revealed no malignancy. MRI revealed multifocal white-matter lesions, …
By: David Willett
Peer reviewed
The story of the pacemaker begins in 1918 in New York City, where Dr. Albert Hyman spent years following his residency studying …
By Felicia Ragucci
Peer Reviewed
My very first patient of clerkship year had the shortest medication list I’ll ever see: none. After confirming this, I asked if she takes over the …